Workshop A Wednesday, September 04

8:30 am - 11:00 am
3D Organoids: Defining & Validating Endpoints in Disease Modeling
Workshop Leader: Caghan Kizil, Group Leader , Center for Neurodegenerative Diseases, Helmholtz Association

Key Outcomes: • Current state-of-the-art of 3D cultures: organoids and biomaterials • The extent of disease modeling in 3D: multiple disease models • Limitations and drawbacks as well as promises and advantages of 3D models • Drug development in 3D – lead generation, optimization, efficacy, PK, and validation: where do we stand? What is the future of 3D cultures? What lies ahead? • Regulatory and funding initiatives for 3D biology

Caghan Kizil, Group Leader , Center for Neurodegenerative Diseases, Helmholtz Association

Neuroscientist and molecular biologist by training. Obtained his PhD from Max Planck Institute for Developmental Biology, Germany in Christiane Nüsslein-Volhard’s laboratory. Currently, a Helmholtz group leader in German Center for Neurodegenerative Diseases (DZNE). Interested in understanding the molecular basis and disease relevance of neural stem cell plasticity in animal and bio-mimetic 3D models of Alzheimer’s disease. His distinctions include Helmholtz Young Investigator Award, DZNE Innovation-to-Application Award, Max Planck Fellowship and several DFG research grants.

Workshop B Wednesday, September 04

12:00 pm - 2:30 pm
Organ-on-Chip Masterclass
Workshop Leader: John Wikswo, Professor and Founding Director , Vanderbilt Institute for Integrative Biosystems Research and Education (VIIBRE)

Key Outcomes:

• Key challenges of microfluidic systems and how to overcome them
• How multi-omic analytical chemistry can inform drug mechanism of action
• Depth of insight into how to model, interconnect, test and control biological systems with allometric, biochemical and/or functional scaling
• The commonalities and differences between organoids, tissue-chips, and organs-on-chips

John Wikswo, Professor and Founding Director , Vanderbilt Institute for Integrative Biosystems Research and Education (VIIBRE)

John Wikswo is the Gordon A. Cain University Professor, the A. B. Learned Professor of Living State Physics, and Professor of Biomedical Engineering, Molecular Physiology and Biophysics, and Physics at Vanderbilt University, and the founding Director of the Vanderbilt Institute for Integrative Biosystems Research and Education (VIIBRE). He received his PhD. from Stanford University. Dr. Wikswo has published more than 200 peer-reviewed papers, is a fellow of seven professional societies, and holds 25 patents.

Workshop C Wednesday, September 04

3:00 pm - 5:30 pm
Quantitative Bright-Field Microscopy Combined with Artificial Neural Networks Predict Live Tissue Function
Workshop Leader: Nathan Hotaling, Lead Data Scientist , National Center for Advancing Translational Sciences (NCATS)

Key Outcomes:

• Validation of IPSC-derived retinal pigment epithelium cultured on biodegradable nanofiber scaffolds for use in a phase I clinical trial

• Next generation of the construct that is being developed in both the microfluidic system and the bioprinted system

Nathan Hotaling, Lead Data Scientist , National Center for Advancing Translational Sciences (NCATS)