Application of 3D Small Intestinal & Colonic Organoids to Assess Clinical Diarrhoea Risk

Time: 2:30 pm
day: Track B - Day 1 PM


  • What are intestinal organoids and why we are using them during development to assess clinical diarrhoea risk for novel oncology medications?
  • Briefly outline limitations of preclinical animals models to assess human diarrhea risk
  • Outlining our experimental approach/capabilities/strategy for intestinal organoid application to support safer drug discovery – include cross-modality and crossspecies data examples
  • Introducing novel predictive models we are developing in AZ to better quantify human diarrhoea risk