Translational Framework for Oral Prodrugs with an Intestine on a Chip Model

Time: 3:30 pm
day: Track B - Day 1 PM

Details:

• A microfluidic organ-on-chip model using human intestine-derived primary cells were established
• Prodrug-specific enzyme expression was confirmed, and the localization was consistent with the intestinal expression in vivo
• Human in vitro to in vivo correlations (IVIVC) was established for commercially available prodrugs using cells from multiple human donors