Stephen Kasper

Stephen Kasper

Company: Merck & Co.

Job title: Exploratory Science Center Scientist

Bio:

I earned my B.S. in Biochemistry and Molecular Biology and Ph.D. in Nanoscale Engineering at the University at Albany, State University of New York, where I developed novel models of pathogenic biofilm formation and used these for phenotypic screens of anti-biofilm compounds and target elucidation. I was a co-founder of a biotech start-up, Empire Biotechnologies Inc., which was focused on the development of protein-based therapeutics for gastrointestinal conditions. I joined the Merck Exploratory Science Center in 2017 and since have been focused on research at the intersection of bioengineering and the human microbiome in the context of oncology, infectious diseases, and cardiometabolic disease.

Seminars:

Novel Host-Microbe In Vitro Model for Colorectal Cancer-Associated Anaerobic Bacteria & Microenvironment 3:30 pm

• Utilize 3D tumor spheroids for novel host-microbe in vitro model development – from screening to microenvironment study • Leverage low oxygen level in the model to ensure anaerobic bacteria survival and proliferation • Evaluate high throughput screening capability and data so far • Explore comparisons with classical models’ readouts • Examine lessons learned and…Read more

day: Day Two

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