8:20 am Check-In & Badge Collection & Coffee
Standardizing Protocols to Enable Effective Reproducibility Across Different Models
9:20 am Chair’s Opening Remarks
9:30 am Balancing Model Complexity with Reproducibility to Drive Adoption of 3D In Vitro Models for Immunology Drug Discovery
Synopsis
- Interrogating best practice to achieve model reproducibility whilst incorporating complexity
- Strategizing practical methods to perform qualification and validation of complex in vitro models
- Realizing experimental design considerations and technologies that enhance the efficiency and throughput of compound screening using 3D tissue models
10:00 am Impact of Technology Selection on iPSC 3D Cell Culture Expansion
Synopsis
- Impact of utilizing various three-dimensional culture systems under both static and dynamic culture conditions for expansion of induced pluripotent stem cells (iPSCs)
- Demonstration of high-throughput analysis of collected iPSC aggregates with rapid processing
- How coupling cell culture technology selection with an accurate measurement system can help ensure critical cell culture attributes are maintained for iPSC 3D cell culture
10:30 am Morning Break & Speed Networking
Synopsis
As the 3D tissue modeling community is reunited, this valuable session will ensure you get the chance to reconnect with peers and make brand new connections! This structured networking opportunity will pair you with fellow attendees for several 3-minute introductions, ensuring you have the opportunity to meet and network with your academic and industry colleagues!
Spotlighting Lessons Learned from Validating 3D Tissue Models Across Multiple Disease Areas
11:30 am Mastermind: Building a General Consensus on Shared Challenges & Differences with Model Validation & Ensuring Reproducibility Across Different CIVMs
Synopsis
- During the first 20 minutes of the session, discuss your challenges and successes with your peers when it comes to validating your model of choice and understanding its context of use and how this changes across the industry
- Spotlight your lessons learned and strategies to safeguard reproducibility in your work
- Soundboard and share innovative ideas and next steps that you can use to improve your current workflows within the final 10 minutes
Moderated by Event Chair
12:00 pm Validating Liver 3D Tissue Models to Advance siRNA Therapeutic Identification
Synopsis
- Utilizing 3D culture systems such as primary human hepatic spheroids (PHHS) and MPS for siRNA therapeutic identification
- Discussing the optimization of 3D cell systems to enhance their utility in siRNA drug development
- Addressing the importance of implementing human specific models to improve better target validation and therapeutic screening
12:30 pm Lunch Break
Enhancing Model Adoption Internally & Externally
1:30 pm Panel: Building Out a Strategy to Increase Model Adoption & Enable Better Alignment with Internal & Regulatory Stakeholders
Synopsis
- Debating what data needs to be produced to instil confidence internally and externally
- Addressing best practices to clearly articulate the value of these models to convince your leadership team and internal stakeholders whether these models are worth of investment
- Discussing the impact from the recent FDA announcement to phase out requirements for animal testing for monoclonal antibodies and other drugs
2:15 pm Discussing Initiatives to Enable Better Alignment on the Use of Complex In Vitro Models with Regulatory Stakeholders
Synopsis
- Reintroducing the IQ-MPS affiliate and the goals of the regulatory working group to qualify CIVMs for regulatory use
- Discussing best practice when interacting with regulatory bodies like the FDA and global regulatory bodies
- Aligning on what CIVM data needs to be produced to instil confidence in the models externally
2:45 pm Scientific Poster Competition & Refreshments Break
Synopsis
Witness some of the latest and greatest research in the 3D tissue modeling field by drug developers, academics, researchers and platform developers in this spotlight poster session! Our poster advisory board will be evaluating the posters as part of the awards process during this time.
Spotlighting Strategies to Validate & Ensure Accurate Recapitulation of Disease for Discovery, ADME & DMPK Studies
3:45 pm Harnessing Reproducible Organ-On-A-Chip Models to Advance Lung Disease Research
Synopsis
- Investigating optimized strategies to recapitulate the disease microenvironment more accurately in organ-on-a-chip models
- Utilizing these models to study fibroblast interactions and their role in lung disease
- Validating the impact of ECM components on the cell co-cultures and target validation efforts in these lung disease models
4:15 pm Validating Skin-Based Complex In Vitro Models to Empower ADME & DMPK Predictions
Synopsis
- Explaining how CIVM provide a more physiologically relevant environment for studying PK, bioavailability and more
- Spotlighting strategies to ensure accurate recapitulation of the tissue microenvironment by using patient tissues
- Linking in vitro data with in vivo data to assess for correlations and empower formulation decision-making