Implementing Strategic In Vitro Model Validation to Accelerate Safe ADC Development & Clinical Translation

  • Establishing model selection criteria for safety assessment to identify appropriate organ systems and predict ADC toxicity endpoints early
  • Implementing 3D to 2D validation strategies to streamline cell-based assays while maintaining predictive accuracy for safety screening
  • Integrating mathematical modeling with in vitro systems to enhance clinical risk prediction and accelerate safer ADC development programs