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8:15 - 17:30 EST | 5:15 - 14:30 PST

8:15 am Morning Coffee Networking

8:50 am Chair’s Opening Remarks

Embedding 3D Models into Your Drug Discovery & Development Program to Guide Clinical Outcomes – Why & How?

9:00 am Human Organs, Physiology & Engineering (HOPE) for Closing the Preclinical Gap

  • Annie Moisan Bioengineering Program Director, Wellcome Leap


• Discover how/if we can double the predictive value of preclinical models
• Place human immune biology at the core of next-generation in vitro platforms: Connecting lymphoid and non-lymphoid tissues
• See demonstrations at convincing scale: Emerging technologies, multi ecosystem experts, metrics and real-world challenges

9:30 am Application of MPS Models in Investigative Toxicology: Current Challenges & Learnings


• Assess how MPS models are currently being applied to toxicology studies
• Gain more robust answers to key toxicity questions
• Apply current learnings to enhance future toxicology studies

10:00 am Fat-on-a-Chip for Drug Discovery & Preclinical Studies

  • Trivia Frazier President & Chief Executive Officer, Obatala Sciences


• Gain insight into the context of unique 3D cell culture capabilities, Faton-a-Chip products and services, and the portfolio of patent-ending and licensed technologies available in this area
• Explore studies that have been conducted and what areas of collaboration and partnership may exist to advance the field and/or conduct drug discovery and preclinical studies

10:20 am From Microphysiological to Micropathophysiological Systems

  • Thomas Hartung Chair for Evidencebased Toxicology & Director CAAT, John Hopkins Bloomberg School of Public Health


• Hear about human-relevant models for drug development and product safety by modelling (patho-) physiology
• Asses quality assurance (GCCP 2.0) and reporting standards
• Gain insights toward a series of MPS world summits and an International society

10:50 am Morning Networking Break


Grab a quick cup of tea or coffee from the comfort of your own home or office and
jump straight into your opportunity to connect with new contacts from active
companies in the fieldto exchange digital business cards. Network and form
lasting connections through this exclusive virtual speed networking

Economic Impacts of In Vitro & 3D Model Adoption

11:20 am Patient-Derived Organoids: the Next-Gen Models for Complex Diseases

  • Sylvia Boj Chief Scientific Officer , Hubrecht Organoid Technology (HUB)


  • The identification of adult stem cells in human epithelia and the development of HUB Organoid Technology
  • In vitro response of HUB Organoids directly correlates with the clinical outcome of the patient from which the organoid was derived.
  • Patient-derived organoids are suitable for being co-cultured with other cell types to represent more complex diseases and study the effect of drugs.

11:40 am Surviving the Technology Hype Cycle: Where MPS Are Having an Impact Today & Where They Are Needed Next


• Understand how to utilize MPS models successfully in your preclinical studies
• Look into the future to see how MPS can have the greatest impact

12:10 pm High-throughput Organ-on-a-Chip Platform for Disease Modeling & Therapeutic Screening


• Unlock novel biology using physiological relevant tissue environments
• Improve drug discovery efforts by applying better and faster assays
• Utilize deep understanding of complex diseases to discover novel therapeutics

12:30 pm Roundtable: How to Foster Collaboration & Select 3D Model Platforms to Scale-Up in Drug Discovery & Development


Led by:

Matthew Lech, Senior Principal Scientist, Pfizer

1:00 pm Networking Lunch

Next Gen 3D Models: A Sneak Peek

2:00 pm Human Organ Chips: Clinical Mimicry in Preclinical Models


• Case study : Serially linking the vascular channels of multiple organ chips to quantitatively predict the tissue-specific distribution of chemicals across an entire system
• Update from Don Ingber’s Lab
• Hear what the future looks like for 3D models: challenges, opportunities and applications

2:30 pm Roundtable Discussion: 3D Microfluidic Disease Models


Join in discussion on the latest in 3D microfluidic models and how they can be successfully applied in drug discovery.

3:00 pm Afternoon Networking Break

3:30 pm Novel Host-Microbe In Vitro Model for Colorectal Cancer-Associated Anaerobic Bacteria & Microenvironment


• Utilize 3D tumor spheroids for novel host-microbe in vitro model development – from screening to microenvironment study
• Leverage low oxygen level in the model to ensure anaerobic bacteria survival and proliferation
• Evaluate high throughput screening capability and data so far
• Explore comparisons with classical models’ readouts
• Examine lessons learned and future direction of plug-and-play

4:00 pm Chips on the Moon

  • Kristin Fabre Chief Scientist; Assistant Professor, Translational Research Institute for Space Health, Baylor College


• Uncover the value that Chips on the Moon brings to research
• Learn how would chips on the moon would benefit terrestrial applications
• Hear what obstacles need to be addressed to accomplish this task
• Explore possible partnerships

4:30 pm Pioneering Bio-Platforms to Directly Handle Multiple Living Cells


• Learn about Bio-electrosprays and Cell electrospinning
• Discover applications for regenerative biology and medicine

5:00 pm Chair’s Closing Remarks

5:10 pm Close of Summit