8:15 am Morning Coffee Networking

8:45 am Chair’s Opening Remarks

Embedding 3D Models into Your Drug Discovery & Development Program to Guide Clinical Outcomes – Why & How?

9:00 am Human Organs, Physiology & Engineering (HOPE) for Closing the Preclinical Gap

  • Annie Moisan Bioengineering Program Director, Wellcome Leap

Synopsis

• Discover how/if we can double the predictive value of preclinical models
• Place human immune biology at the core of next-generation in vitro platforms: Connecting lymphoid and non-lymphoid tissues
• See demonstrations at convincing scale: Emerging technologies, multi ecosystem experts, metrics and real-world challenges

9:30 am Application of MPS Models in Investigative Toxicology: Current Challenges & Learnings

Synopsis

• Assess how MPS models are currently being applied to toxicology studies
• Gain more robust answers to key toxicity questions
• Apply current learnings to enhance future toxicology studies

10:00 am Fat-on-a-Chip for Drug Discovery & Preclinical Studies

  • Trivia Frazier President & Chief Executive Officer, Obatala Sciences

Synopsis

• Gain insight into the context of unique 3D cell culture capabilities, Faton-a-Chip products and services, and the portfolio of patent-ending and licensed technologies available in this area
• Explore studies that have been conducted and what areas of collaboration and partnership may exist to advance the field and/or conduct drug discovery and preclinical studies

10:15 am From Microphysiological to Micropathophysiological Systems

  • Thomas Hartung Chair for Evidencebased Toxicology & Director CAAT, John Hopkins Bloomberg School of Public Health

Synopsis

• Hear about human-relevant models for drug development and product safety by modelling (patho-) physiology
• Asses quality assurance (GCCP 2.0) and reporting standards
• Gain insights toward a series of MPS world summits and an International society

10:45 am High-throughput Organ-on-a-Chip Platform for Disease Modeling & Therapeutic Screening

Synopsis

• Unlock novel biology using physiological relevant tissue environments
• Improve drug discovery efforts by applying better and faster assays
• Utilize deep understanding of complex diseases to discover novel therapeutics

Economic Impacts of In Vitro & 3D Model Adoption

11:30 am Surviving the Technology Hype Cycle: Where MPS Are Having an Impact Today & Where They Are Needed Next

Synopsis

• Understand how to utilize MPS models successfully in your preclinical studies
• Look into the future to see how MPS can have the greatest impact

12:00 pm Roundtable: How to Foster Collaboration & Select 3D Model Platforms to Scale-Up in Drug Discovery & Development

Synopsis

Led by:

Matthew Lech, Senior Principal Scientist, Pfizer

12:30 pm Networking Lunch

Next Gen 3D Models: A Sneak Peek

1:30 pm Body on a Chip: Reimagining Drug Testing

Synopsis

• Case study : Serially linking the vascular channels of multiple organ chips to quantitatively predict the tissue-specific distribution of chemicals across an entire system
• Update from Don Ingber’s Lab
• Hear what the future looks like for 3D models: challenges, opportunities and applications

2:00 pm Chips on the Moon

  • Kristin Fabre Chief Scientist; Assistant Professor, Translational Research Institute for Space Health, Baylor College

Synopsis

• Uncover the value that Chips on the Moon brings to research
• Learn how would chips on the moon would benefit terrestrial applications
• Hear what obstacles need to be addressed to accomplish this task
• Explore possible partnerships

2:30 pm Novel Host-Microbe In Vitro Model for Colorectal Cancer-Associated Anaerobic Bacteria & Microenvironment

Synopsis

• Utilize 3D tumor spheroids for novel host-microbe in vitro model development – from screening to microenvironment study
• Leverage low oxygen level in the model to ensure anaerobic bacteria survival and proliferation
• Evaluate high throughput screening capability and data so far
• Explore comparisons with classical models’ readouts
• Examine lessons learned and future direction of plug-and-play

3:00 pm Roundtable Discussion – Exploiting Technologies to Advance your 3D Models for Candidate Progression

Share your thoughts and address key challenges across the industry alongside 100+ preclinical experts. Choose one of the following interactive discussions to gain practical top tips and a flavor of novel platforms, to aid your preclinical and translational studies!

3D Bioprinting

  • What are the latest advancements in the area?
  • Can bio-printed models be used for screening and drug development?
  • What are the current barriers to adoption for this technology?

Flow Cytometry vs Cell Sorting

  • Evaluate high throughput screening and flow cytometry to increase efficiency
  • What are the limitations of each technique and what needs to be done to overcome these?

Modifying Microfluidic Models

  • Discuss the latest progress in the modification of micro-fluidics
  • What needs to change for microfluidic systems to be readily adopted in the industry?

3:30 pm Afternoon Networking Break

4:00 pm Complex 3D Microfluidic Disease Model with Multiple Cell Types

Synopsis

• Assess high throughput co-culture organotypic models for oncology screening
• Uncover liver microphysiological systems for metabolic disease modeling

4:30 pm Pioneering Bio-Platforms to Directly Handle Multiple Living Cells

Synopsis

• Learn about Bio-electrosprays and Cell electrospinning
• Discover applications for regenerative biology and medicine

5:00 pm Let’s Take a Closer Look through a Powerful Lens – Real Time Imaging

  • Steve Titus Scientific Leader Functional Genomics, GlaxoSmithKline

Synopsis

• Discuss state-of-the-art methodologies used for the characterization and visualization of 3D models
• Explore 3D live-cell imaging – assay development to capture the changes
• Discuss a data analysis platforms and storage options large 3D kinetic data sets

5:30 pm Chair’s Closing Remarks

5:45 pm Close of Summit